First in-beam tests on simultaneous PET and Compton imaging aimed at quasi-real-time range verification in hadron therapy

Hadron therapy with protons has advantages respect to conventional radiotherapy because of the maximization dose at Bragg peak. As a drawback, and different systematic uncertainty sources, quasi-real time monitoring for proton range verification is required reduce safety margins. In this respect, two gamma-ray imaging techniques are pursued: prompt positron-annihilation tomography (PET). The promising requires detection systems large efficiency, high resolution, compactness, fast response, low sensitivity neutron-induced backgrounds powerful image reconstruction capabilities. On other hand, in-beam PET surveys require additionally good γ-ray position resolution. contribution we show that, extent, both approaches can be simultaneously accomplished by using an array Compton cameras conveniently arranged around target volume. Here demonstrate experimentally suitability such array, named i-TED, PG in ion-range during Therapy, survey β + production yield measurements capability. Furthermore, use GPUs, achieved.